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About Hemp Care

RENatural’s Hemp C B D is safe, legal, organic, non-psychoactive, and triple tested for quality, potency, and purity.

Article “Cliff Notes”: The Health Benefits of C B-D: What the Research is Showing
* Neuroprotective and Antioxidant Effects
* Anti-Anxiety & Mood Enhancement
* Anti-Inflammatory & Pain Reduction
* Nausea, Diabetes, Epilepsy and More
* Potential Anti-tumor Effects on gliomas and breast carcinomas (in vitro)

C B -D has an affinity for activating serotonin receptors (specifically 5-HT1A), which control anxiety, calmness and mood; vanilloid receptors, which control and modulate how we experience pain; adenosine receptors, which control the quality and depth of our sleep; and indirectly influences endocannabinoid receptors, which control memory, energy levels, stress levels, pain tolerance, body temperature and appetite, among many others things.

Read on for article excerpts and links to peer-reviewed, medical research studies.

The Health Benefits of C B -D: What The Research is Showing

So just what is so great about C B -D oil’s benefits that is causing so much interest and research in both the scientific and medical communities? To understand that properly, it’s important to understand how C B D works in the body and mind.

1. Neuroprotective and Antioxidant Effects

Of all C B -D’s reported effects one of its most novel and interesting is neuroprotection, which is believed to stem from its ability to act as a powerful antioxidant in the brain. Neuroprotection loosely refers to the ability of Cannabidiol—as shown in a number of animal studies—to a) prevent, mitigate, reverse or interrupt many of the processes that lead to the breakdown of neurons in the brain and nervous system believed to cause many common diseases like Parkinson’s, Alzheimer’s, MS, strokes and more, and b) reduce inflammation in the brain, which is believed by many doctors to interfere with brain function and play a role in mystery illnesses like chronic fatigue and brain fog. [5-11] Although neuroprotective effects have currently only been demonstrated in animal models and cell cultures, there is hope that C B -D may exert similar effects in humans, though further research is needed.

2. Anti-Anxiety & Mood Enhancement

One of the most noticeable effects that many people report after taking C B -D oil is a pleasant and powerful reduction in anxiety and a noticeable lift in mood. Many describe feeling a wave of calm and bliss washing over their bodies, which is consistent with C B -D’s reported effects at 5-HT receptors that control the release of many important neurotransmitters that affect stress/anxiety levels and mood, particularly serotonin.

One study of C B -D extract on anxiety used functional magnetic resonance imaging (fMRI), which is a sophisticated brain activity mapping tool, to study what happened to the brain when participants took 600mg of C B -D extract while being exposed to stress- and anxiety-inducing stimuli. What they found was that C B -D calmed the amygdala and cingulate cortex, two important areas of the brain well-known to control fear, stress levels and anxiety, among other things. [12]
In another study, Brazilian researchers investigated the effect of C B -D extract on human cortisol levels in eleven volunteers. They found that C B -D decreased cortisol levels significantly more than the placebo and that most subjects also reported a sedative effect from the treatment. [14]

In a meta-aalysis of C B -D’s effects on anxiety conducted in Brazil, researchers found that “studies using animal models of anxiety and involving healthy [human] volunteers clearly suggest an anxiolytic-like effect of C B -D. Moreover, Cannabidiol extract was shown to reduce anxiety in [human] patients with social anxiety disorder.” [13] For this reason, C B -D is also being investigated as a natural antidepressant, anti-psychotic, and an alternative to SSRI medications (Prozac, etc.).

3. Anti-Inflammatory & Pain Reduction

Multiple animal studies have shown that C B -D has a remarkable ability to suppress certain cellular processes that lead to inflammation and, as a result, pain. [5-7,15-17] Researchers are currently conducting studies to see just how much this effect transfers over to humans, but there have been a number of clinical trials in Europe on a product called Sativex, which is a 1:1 blend of C B -D and t h c. These studies found that Sativex was able to reduce pain associated with central and peripheral neuropathy, rheumatoid arthritis, and cancer to varying degrees in most of the study participants. [18-19] It is unclear how much of an effect Cannabidiol has on pain reduction in these cases, however, the animal studies suggest that C B -D is likely involved to some degree based on its known effects on cellular processes.

Although the jury is still out as to how effective C B -D oils and extracts are for inflammation, many who have been struggling with inflammation-related diseases like arthritis have reported that C B -D oils, extracts and creams containing C B -D have helped reduce some of their symptoms.

4. Nausea, Diabetes, Epilepsy and More

Although not as common, studies on animals and a few, small human studies (in the case of epilepsy) also found that Cannabidiol shows promise as a potential treatment for seizures, diabetes and nausea, among other things, although more research is needed. [20-25] Three of the four human studies done using C B -D as a treatment for epilepsy showed positive results, however, due to design flaws and lack of rigor, most researchers are suggesting that the currently available information is insufficient to draw firm conclusions regarding the efficacy of C B -D as a treatment for seizures. [26] Studies are currently underway to get better data based on initial promising results in animal trials.

Researchers have also found in experimental animal and human cell culture models (meaning that they are exposing human and animal cells to various concentrations of C B -D in petri dishes and test tubes in the lab) that C B -D has anti-tumor effects on glioma and breast carcinomas and results in increased cancer cell death in certain types of cancers. [2-4] As it currently stands, it’s a big leap from the test tube to the human body, and no definitive claims can be made in this regard, nonetheless many in the scientific community are watching these developments very closely.

Quality & Potency

More so than other herbs and plants, quality can be an issue with certain C B -D products, so it’s important to seek out brands with a high degree of integrity that clearly disclose their sourcing practices and quality standards. Seek products that are completely organic or at least contain organic C B -D as these are guaranteed to be free of harmful chemicals and solvents that are sometimes used in the extraction process of less-reputable companies just out to make a buck.

All widely available, legal C B -D products are extracted from the hemp plant, and particularly hemp oil, whereas products that are legal in some places but illegal in others (depending on local jurisdiction) are often extracted from cannabis (marijuana) plants and contain significant and varying levels of t h c. There is some evidence that small amounts of t h c increase the effectiveness of C B -D, however, it is not required to reap the benefits of taking Cannabidiol. Research has shown pure C B -D extracts from hemp and hemp oil, as long as the C B -D is of high quality, are similarly effective and beneficial. However, in more serious, chronic illnesses there may be additional benefits from having t h c in the mixture, such as more pronounced pain reduction and medicinal effects, according to the various human studies conducted on the compound. [27-28]

It is also important to consider potency when choosing C B -D products as well. Generally speaking, the effects of C B -D are dose dependent to some degree, meaning that the more that is ingested, the more pronounced its effects are. As such, it’s important to seek out more concentrated and/or highly absorbable products for maximum effect. There are a wide range of Cannabidiol product potencies available, but a good starting point for most people is for one dose of the product to be in the 2mg to 7mg range, with the latter being on the stronger side. If you know you tend to be sensitive to natural products and medicines, start at a lower dose. If you don’t tend to feel anything or know you need a stronger product to notice the benefits of C B -D, feel free to start with higher dosages. For most C B -D hemp oil products, you can take a partial or double dose to adjust the potency.

C B -D oil is remarkably safe and has shown itself to be relatively side-effect free so there’s nothing to worry about unless you have a known allergy to hemp or you are on some type of medication or medical supervision. When in doubt consult a qualified naturopath or doctor. As always, when starting new herbs or natural medicines like Cannabidiol, be sure to start slow to understand how your body reacts and work up to higher dosages over time.


References
[1] Volkow, Nora D. “Cannabidiol: Barriers to Research and Potential Medical Benefits.” Drug Caucus Hearing on Barriers to Cannabidiol Research, United States Senate Caucus on International Narcotics Control. June 24, 2015 Retrieved from
https://www.drugabuse.gov/about-nida/legislative-activities/testimony-to-congress/2016/biology-potential-therapeutic-effects-cannabidiol
[2] Ligresti et al. “Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma.” J Pharmacol Exp Ther 318.3 (2006): 1375-1387.
[3] Massi et al. “Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines.” J Pharmacol Exp Ther 308.3 (2004): 838-845.
[4] McAllister et al. “The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids.” J Neuroimmune Pharmacol 10.2 (2015): 255-267.
[5] Esposito et al. “The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells.” J Mol Med (Berl) 84.3 (2006): 253-258.
[6] Martín-Moreno et al. “Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer’s disease.” Mol Pharmacol 79.6 (2011): 964-973.
[7] Iuvone et al. “Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells.” J Neurochem 89.1 (2004): 134-141.
[8] Pazos et al. “Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: role of 5-HT1A and CB2 receptors.” Neuropharmacology 71 (2013): 282-291.
[9] Hampson et al. “Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants.” Proc Natl Acad Sci USA 95.14 (1998): 8268-8273.
[10] Pryce et al. “Neuroprotection in Experimental Autoimmune Encephalomyelitis and Progressive Multiple Sclerosis by Cannabis-Based Cannabinoids.” J Neuroimmune Pharmacol 10.2 (2015): 281-292.
[11] García-Arencibia et al. “Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson’s disease: importance of antioxidant and cannabinoid receptor-independent properties.” Brain Res 1134.1 (2007): 162-170.
[12] Fusar-Poli et al. “Distinct effects of delta-9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing.” Arch Gen Psychiatry 66.1 (2009): 95-105.
[13] Schier et al. “Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug.” Rev Bras Psiquiatr, 34.1 (2012): 104-110.
[14] Zuardi et al. “Effect of cannabidiol on plasma prolactin, growth hormone, and cortisol in human volunteers.” Braz J of Med and Biol Res 26.2 (1993): 213–217.
[15] Malfait et al. “The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.” Proc Natl Acad Sci USA 97.17 (2000): 9561-9566.
[16] Costa et al. “Oral anti-inflammatory activity of cannabidiol, a nonpsychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw.” Naunyn Schmiedebergs Arch Pharmacol 369.3 (2004): 294-299.
[17] Costa et al. “The nonpsychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain.” Eur J Pharmacol. 556.1-3 (2006): 75-83.
[18] Di Marzo, Vincenzo and Diego Centonze. ‘Placebo effects in a multiple sclerosis spasticity enriched clinical trial with the oromucosal cannabinoid spray (): dimension and possible causes.” CNS Neurosci Ther. 21.3 (2015): 215-21.
[19] Flachenecker et al. “Nabiximols  oromucosal spray, Sativex®) in clinical practice–results of a multicenter, non-interventional study (MOVE 2) in patients with multiple sclerosis spasticity.” Eur Neurol. 71.5-6 (2014): 271-279.
[20] Porter, Brenda E. and Catherine Jacobson “Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy.” Epilepsy & Behavior 29 (2013) 574–577.
[21] Cunha et al. “Chronic administration of cannabidiol to healthy volunteers and epileptic patients.” Pharmacology 21.3 (1980): 175-185.
[22] Parker et al. “Cannabidiol, a nonpsychoactive component of cannabis and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats.” Neuroreport. 13.5 (2002): 567-570.
[23] Weiss et al. “Cannabidiol lowers incidence of diabetes in non-obese diabetic mice.” Autoimmunity. 39.2 (2006): 143-151.
[24] Rajesh et al. “Cannabidiol attenuates high glucoseinduced endothelial cell inflammatory response and barrier disruption.” Am J Physiol Heart Circ. Physiol. 293.1 (2007): H610-H619.
[25] Porter, Brenda E. and Catherine Jacobson. “Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy.” Epilepsy & Behavior 29.3 (2013): 574–577.
[26] Lee, Martin A. “CB-DMisconceptions.” Project CB-D. February 18, 2015. Accessed October 28, 2016. https://www.projectcbd.org/article/cbd-misconceptions.
[27] Russo, Ethan B. “Taming TH-C: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.” Br J Pharmacol. 163.7 (2011): 1344-1364.